Stability of β-catenin as a potential mechanism of glucocorticoid dependant expansion of human erythroid progenitors

Abstract

Introduction: Cooperative signalling between the glucocorticoid nuclear receptor and the cytokine receptors was proven to be central for proper balance between progenitor proliferation and differentiation. The glucocorticoid, Dexamethasone (Dex) has been identified as an essential requirement for the generation of mass cultures of erythroblasts. The production of massive cultures of human red blood cells in vitro would possibly lead to ex vivo transfusions. Although many signalling pathways have been unravelled, transcription regulation induced by glucocorticoids in haematopoietic progenitors is still unclear.