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https://www.um.edu.mt/library/oar/handle/123456789/2014
Title: | The structure of protein molecules : in celebration of the International Year of Crystallography, 2014 |
Authors: | Hunter, Gary J. Vella, Marita Bonetta, Rosalin Farrugia, Diane Hunter, Therese |
Keywords: | X-ray crystallography Proteins |
Issue Date: | 2014 |
Publisher: | Malta Chamber of Scientists |
Citation: | Xjenza. 2014, Vol.2(1), p. 42-47 |
Abstract: | Many people, including laymen, are aware of the double helical nature of the DNA molecule. A few may actually realise that it was the technique of X-ray crystallography that was the key to solving this structure. Even fewer will understand the uses and applications of crystallography to the most diverse of biological materials; proteins. In this review we discuss the application of a number of methodologies required to progress from a cloned gene to protein expression and purification, crystallisation conditions and eventually to X-ray structure determination. We provide our own experience in the field as examples of the procedures required. Protein crystallographers worldwide are contributing to our understanding of how enzymes work, how our immune system defends us against viruses and are using structural information to design novel pharmaceutical reagents. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/2014 |
Appears in Collections: | Scholarly Works - CenMMB Scholarly Works - FacM&SPB Xjenza, 2014, Volume 2, Issue 1 Xjenza, 2014, Volume 2, Issue 1 |
Files in This Item:
File | Description | Size | Format | |
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The Structure of Protein Molecules In Celebration of the International Year of Crystallography, 2014.pdf | 2.39 MB | Adobe PDF | View/Open |
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