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https://www.um.edu.mt/library/oar/handle/123456789/77918
Title: | Identifying compounds that enhance the resilience of isolated neuronal mitochondria against dysfunction induced by Aß42 and tau oligomers |
Authors: | Zarb, Claire M (2012) |
Keywords: | Mitochondria Oligomers Conjugated oligomers |
Issue Date: | 2012 |
Citation: | Zarb, C. M. (2012). Identifying compounds that enhance the resilience of isolated neuronal mitochondria against dysfunction induced by Aß42 and tau oligomers (Master's dissertation). |
Abstract: | The oligomeric intraneuronal accumulation of amyloid beta AB42 (AB42 ) and Tau has been directly linked to Alzheimer's Disease (AD) pathology and progression. In particular, mounting evidence indicates that oligomer-induced mitochondrial abnormalities are early occurrences, preceding neurological pathology and clinical symptoms characteristic of AD. Perforation of mitochondrial membranes leads to the release of pro-apoptotic proteins such as cytochrome c into the cellular cytosol, triggering neuronal apoptosis. The main aims of the study were to determine any effects of Ab42 and Tau aggregates on mitochondrial membranes and subsequently identify mitochondrial-protective compounds. The rationale behind the study was to gain further insight as to the mechanisms involved in AbTau induced mito-toxicity, and identify potential candidates for effective mitochondrial drugs in AD. |
Description: | M.SC.PHARMACOLOGY |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/77918 |
Appears in Collections: | Dissertations - FacM&S - 2012 Dissertations - FacM&SCPT - 2012 |
Files in This Item:
File | Description | Size | Format | |
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M.SC.PHARMACOLOGY_Zarb_Claire_ M_2012.pdf Restricted Access | 9.44 MB | Adobe PDF | View/Open Request a copy |
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