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Title: | Review : the use of umbilical cord stem cells as a form of treatment |
Authors: | Azzopardi, Joseph Ignatius Blundell, Renald |
Keywords: | Stem cells Embryonic stem cells Adult stem cells Umbilical cord |
Issue Date: | 2018 |
Publisher: | University of Malta. Department of Physiology and Biochemistry |
Citation: | Azzopardi, J. I., & Blundell, R. (2018). Review: the use of umbilical cord stem cells as a form of treatment. University of Malta. Department of Physiology and Biochemistry |
Abstract: | Stem cells are a type of cells that can self-renew and undergo lineage differentiation – this is what is known as “developmental plasticity”. Once regarded as a waste product, the umbilical cord was found to be a good source of hematopoietic and mesenchymal stem cells in 1974, with the first successful transplantation occurring in 1988. The use of umbilical cord as a source of hematopoietic stem cells for transplantation has many advantages over other sources of haematopoietic stem cells, namely the bone marrow. Advantages include a larger amount of stem cells per unit volume, decreased risk of transmission of Epstein-Barr virus and cytomegalovirus infections, greater tolerance of Human Leukocyte Antigen (HLA) mismatches and the ability to be stored in a bank. In this review, we assessed the safety and efficacy of using umbilical cord blood-derived stem cells as treatment for different diseases by looking into some of the latest clinical cases. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/81283 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Review.pdf | 192.48 kB | Adobe PDF | View/Open |
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