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Title: | Anti-Parkinson’s evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals |
Authors: | Saleem, Uzma Bibi, Shabana Shah, Muhammad Ajmal Ahmad, Bashir Saleem, Ammara Chauhdary, Zunera Anwar, Fareeha Javaid, Nimra Hira, Sundas Akhtar, Muhammad Furqan Shah, Ghulam Mujtaba Khan, Muhammad Saad Muhammad, Haji Qasim, Muhammad Alqarni, Mohammad Algarni, Majed A. Blundell, Renald Vargas-de la Cruz, Celia Herrera-Calderon, Oscar Alhasani, Reem Hasaballah |
Keywords: | Parkinson’s disease Cellular therapy Oxidative stress Antioxidants Nervous system -- Degeneration Neuroprotective agents |
Issue Date: | 2021 |
Publisher: | Frontiers |
Citation: | Saleem, U., Bibi, S., Shah, M. A., Ahmad, B., Saleem, A., Chauhdary, Z.,... Alhasani, R. H. (2021). Anti-Parkinson’s evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals. Frontiers in Bioscience-Landmark, 2. 1-21. |
Abstract: | Parkinson’s disease (PD) is asso-
ciated with progressive neuronal damage and dysfunction.
Oxidative stress helps to regulate neurodegenerative and
neuronal dysfunction. Natural compounds could attenuate
oxidative stress in a variety of neurological disorders. B.
juncea is a rich source of antioxidants. The present study
aimed to evaluate the therapeutic potential of B. juncea
leaves for the treatment of PD by applying behavioral, in
vivo and in silico studies. For in vivo studies rats were
divided into six groups (n = 6). Group-I served as nor-
mal control (vehicle control). Group-II was disease con-
trol (haloperidol 1 mg/kg). Group-III was kept as a stan-
dard group (L-Dopa 100 mg/kg + carbidopa 25 mg/kg).
Groups (IV–VI) were the treatment groups, receiving ex-
tract at 200-, 400- and 600 mg/kg doses respectively, for 21
days orally. Results: In vivo study results showed that the extract was found to improve muscles strength, motor co- ordination, and balance in PD. These behavioral outcomes were consistent with the recovery of endogenous antioxi- dant defence in biochemical analysis which was further cor- roborated with histopathological ameliorations. Dopamine levels increased and monoamine oxidase B (MAO-B) levels decreased dose-dependently in the brain during the study. Herein, we performed molecular docking analysis of the proposed extracted phytochemicals has explained that four putative phytochemicals (sinapic acid, rutin, ferulic acid, and caffeic acid) have presented very good results in terms of protein-ligand binding interactions as well as absorption, distribution, metabolism, excretion & toxicity (ADMET) profile estimations. Conclusion: The undertaken study concluded the anti-Parkinson activity of B. juncea and fur- ther suggests developments on its isolated compounds in PD therapeutics. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/84810 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Landmark21060205-V2 (1).pdf | 15.93 MB | Adobe PDF | View/Open |
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