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https://www.um.edu.mt/library/oar/handle/123456789/87251| Title: | The effect of DOAC-Stop® on several oral and parenteral anticoagulants |
| Authors: | Riva, Nicoletta Hickey, Kieron Gatt, Peter Grima, Charlie Zammit, Daniel Ageno, Walter Kitchen, Steve Makris, Michael Gatt, Alexander Vella, Kevin |
| Keywords: | Anticoagulants (Medicine) Anticoagulants (Medicine) -- Administration |
| Issue Date: | 2021 |
| Publisher: | Wiley Online Library |
| Citation: | Riva, N., Vella, K., Hickey, K., Gatt, P., Grima, C., Zammit, D., ... & Gatt, A. (2021). The effect of DOAC-Stop® on several oral and parenteral anticoagulants. International Journal of Laboratory Hematology, 43, e171–e175. |
| Abstract: | DOAC-Stop® is a hydrophobic binding agent, containing activated charcoal, which can absorb the direct oral anticoagulants (DOACs) from plasma samples in vitro.1 It neutralized the effect of apixaban, edoxaban, rivaroxaban and dabigatran on routine coagulation assays, such as activated partial thromboplastin time (aPTT) and prothrombin time (PT)/international normalized ratio (INR).1-3 It has been proposed that DOAC-Stop® not only can identify which samples with prolonged coagulation assay results actually contain the DOACs,1 but might also aid in estimating the DOAC concentration by calculating a “correction ratio” of aPTT before/after DOAC-Stop® treatment, if the reagents are adequately sensitive to the DOACs.4 |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/87251 |
| Appears in Collections: | Scholarly Works - FacEngEE Scholarly Works - FacM&SPat |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| The effect of DOAC-Stop.pdf Restricted Access | 956.74 kB | Adobe PDF | View/Open Request a copy |
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