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Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/88491
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dc.contributor.authorMifsud, Janet-
dc.contributor.authorShabbi, H.-
dc.contributor.authorSoler, D.-
dc.date.accessioned2022-02-08T07:34:49Z-
dc.date.available2022-02-08T07:34:49Z-
dc.date.issued2006-09-
dc.identifier.citationMifsud, J., Shabbi, H., & Soler, D. (2006). Modelling pharmacokinetics for antiepileptic drugs in paediatrics. European Journal of Neurology, 13(s2), 122-123.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/88491-
dc.description.abstractAIMS: Most physicians use ad hoc reasoning in the design of dosage regimens for antiepileptic drugs in children as there is still a lack of satisfactory models and software packages that will allow accurate predictions of drug levels.en_GB
dc.description.abstractMETHODS: In this study, the value of a sparse data model, using Adapt® software was developed for lamotrigine in paediatric patients. Plasma lamotrigine levels in 20 paediatric patients were measured. The pharmacokinetic parameters in the four groups(lamotrigine alone, valproate co-medication group, carbamazepine co-medication group, and clonazepam co-medication group) were estimated in this study using model independent pharmacokinetic equations.en_GB
dc.description.abstract[excerpt]en_GB
dc.language.isoenen_GB
dc.publisherJohn Wiley & Sons, Inc.en_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectPharmacokinetics -- Mathematical modelsen_GB
dc.subjectPharmacokinetics -- Data processingen_GB
dc.subjectAnticonvulsants -- Mechanism of actionen_GB
dc.subjectEpilepsy in childrenen_GB
dc.titleModelling pharmacokinetics for antiepileptic drugs in paediatricsen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.bibliographicCitation.conferencename10th Congress of the EFNSen_GB
dc.bibliographicCitation.conferenceplaceGlasgow, UK, 2006en_GB
dc.description.reviewedpeer-revieweden_GB
dc.publication.titleEuropean Journal of Neurologyen_GB
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