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https://www.um.edu.mt/library/oar/handle/123456789/88492
Title: | Therapeutic drug monitoring of lamotrigine in a paediatric population |
Authors: | Mifsud, Janet Shabbi, H. Soler, D. |
Keywords: | Drug monitoring Drug interactions Lamotrigine Epilepsy in children Anticonvulsants |
Issue Date: | 2006-12 |
Publisher: | John Wiley & Sons, Inc. |
Citation: | Mifsud, J., Shabbi, H., & Soler, D. (2006). Therapeutic drug monitoring of lamotrigine in a paediatric population. Epilepsia, 47(s3), 124-125. |
Abstract: | PURPOSE: Therapeutic drug monitoring is important for drugs that exhibit interindividual variability in pharmacokinetics, and where drug-drug interactions, concurrent disease or age alters the kinetics of that drug. This is of particular importance in a chronic neurological condition such as epilepsy. In this study, the value of therapeutic drug monitoring for lamotrigine, a novel antiepileptic drug, was investigated in a group of paediatric patients. METHOD: Plasma lamotrigine levels in 20 paediatric patients (mean ±S.D., age 8.85±3.47 years and weight, 32.22±20.81 kg) were measured using a novel validated high performance liquid chromatography (HPLC) technique that gave a retention time for lamotrigine and internal standard of 1.258 min and 2.30 min respectively. The method proved to be linear, precise and reproducible over the plasma concentration range of 0.08–20mg/. [excerpt] |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/88492 |
Appears in Collections: | Scholarly Works - FacM&SCPT |
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Therapeutic drug monitoring of lamotrigine in a paediatric population.pdf Restricted Access | 48.3 kB | Adobe PDF | View/Open Request a copy |
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