Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/90535
Title: | Intracerebral human microdialysis in Parkinson’s disease |
Other Titles: | Microdialysis techniques in neuroscience |
Authors: | Galati, Salvatore Di Giovanni, Giuseppe |
Keywords: | Brain microdialysis Deep brain stimulation Parkinson's disease Subthalamic nucleus Substantia nigra Basal ganglia |
Issue Date: | 2013 |
Publisher: | Humana Press |
Citation: | Galati, S., & Di Giovanni, G. (2013). Intracerebral human microdialysis in Parkinson’s disease. In: G. Di Giovanni, V. Di Matteo (eds.), Microdialysis Techniques in Neuroscience (pp. 209-223). Totowa: Humana Press. |
Abstract: | Microdialysis (MD) procedure is a versatile technique that allows the analysis of small molecular weight compounds from the interstitial space in different tissues. MD was used extensively in neuroscience animal studies at the end of last century, while only a single MD study in the human brain was performed at the end of 1980s. In contrast, over the last decade MD has been applied in humans mainly in neurological disorders, such as stroke, epilepsy, and Parkinson’s disease (PD). In these disorders MD has allowed quantification of neurotransmitters, peptides, and hormones giving precious information in research as well as in clinical practice. Microdialysis in awake PD patients in conjunction with deep brain stimulation (DBS) surgery has received increasing interest, but is nonetheless still a novel approach. It is likely that MD will be instrumental as a research tool in clarifying important open issues relating to the basal ganglia functions and dysfunctions. The present chapter will summarize the principles of MD and its involvement in research studies in PD in humans, illuminating the limits and the future applications of this procedure. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/90535 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Intracerebral Human Microdialysis in Parkinson’s Disease.pdf Restricted Access | 386.65 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.