Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/92732
Title: | Noncoding RNAs in age-related cardiovascular diseases |
Authors: | Jusic, Amela Thomas, Pınar Buket Bezzina Wettinger, Stephanie Doğan, Soner Farrugia, Rosienne Gaetano, Carlo Güvenç Tuna, Bilge Pinet, Florence Robinson, Emma L. Tual-Chalot, Simon Stellos, Konstantinos Devaux, Yvan |
Keywords: | Non-coding RNA Cardiovascular system -- Diseases Cardiovascular system -- Diseases -- Diagnosis Cardiovascular system -- Diseases -- Treatment |
Issue Date: | 2022 |
Publisher: | Elsevier |
Citation: | Jusic, A., Thomas, P. B., Wettinger, S. B., Doğan, S., Farrugia, R., Gaetano, C., ... & Devaux, Y. (2022). Noncoding RNAs in age-related cardiovascular diseases. Ageing Research Reviews, 77, 101610. |
Abstract: | Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/92732 |
Appears in Collections: | Scholarly Works - FacHScABS |
Files in This Item:
File | Description | Size | Format | |
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Noncoding RNAs in age-related cardiovascular diseases.pdf Restricted Access | 2.78 MB | Adobe PDF | View/Open Request a copy |
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