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Title: | The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology |
Authors: | Hernandez, Ana Martinez Urbanke, Hendrik Gillman, Alan L. Lee, Joon Ryazanov, Sergey Agbemenyah, Hope Y. Benito, Eva Jain, Gaurav Kaurani, Lalit Grigorian, Gayane Leonov, Andrei Rezaei-Ghaleh, Nasrollah Wilken, Petra Teran Arce, Fernando Wagner, Jens Fuhrman, Martin Caruana Grech Perry, Mario Camilleri, Angelique Vassallo, Neville Zweckstetter, Markus Benz, Roland Giese, Armin Schneider, Anja Korte, Martin Lal, Ratnesh Griesinger, Christian Eichele, Gregor Fischer, Andre |
Keywords: | Alzheimer's disease -- Pathophysiology Alzheimer's disease -- Treatment Amyloid beta-protein Nervous system -- Degeneration Plaque, amyloid -- Physiopathology |
Issue Date: | 2018 |
Publisher: | EMBOpress |
Citation: | Martinez Hernandez, A., Urbanke, H., Gillman, A. L., Lee, J., Ryazanov, S., Agbemenyah, H. Y.,... Fischer, A. (2018). The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine, 10(1), 32-47. |
Abstract: | Alzheimer’s disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer’s disease, when given orally before or after the onset of pathology. At the mechanistic level, we provide evidence that anle138b blocks the activity of conducting Ab pores without changing the membrane embedded Ab-oligomer structure. In conclusion, our data suggest that anle138b is a novel and promising compound to treat AD-related pathology that should be investigated further. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/93039 |
Appears in Collections: | Scholarly Works - FacHScFSEH |
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The_diphenylpyrazole_compound_anle138b_blocks_AB_channels_and_rescues_disease_phenotypes_in_a_mouse_model_for_amyloid_pathology_2018.pdf | 1.95 MB | Adobe PDF | View/Open |
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