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Title: | Relationship of whole brain volume MRI measures to neuropsychological performance in schizophrenic and healthy subjects |
Authors: | Toulopoulou, T. Grech, Anton Sharma, T. Morris, R. G. Rabe-Hesketh, S. Yakeley, J. Murray, R. M. |
Keywords: | Brain -- Physiology Schizophrenics -- Case studies Brain -- Magnetic resonance imaging Neuropsychological tests WAIS-R Digit Span subtest |
Issue Date: | 2000 |
Publisher: | Elsevier |
Citation: | Toulopoulou, T., Grech, A., Sharma, T., Morris, R. G., Rabe-Hesketh, S., Yakeley, J., & Murray, R. M. (2000). Relationship of whole brain volume MRI measures to neuropsychological performance in schizophrenic and healthy subjects. Schizophrenia Research, 41(1), 122-123. |
Abstract: | Objective: To explore the relationship between whole brain volume MRI measures and performance on neuropsychological tests of intelligence, memory and shifting mental sets. Methods: Sixteen schizophrenic patients and 16 unrelated healthy controls matched for age, sex, handedness and social class underwent a series of neuropsychological assessments and a brain magnetic resonance imaging (MRI) scan. Neuropsychological function was assessed by administering a battery of tests including tests of: (1) Intelligence, assessed by the Wechsler Adult Intelligence Scale-Revised (WAIS-R); (2) Memory, measured by Russell's (1975) version of the Wechsler Memory Scale (WMS); and (3) Shifting Mental Sets, tested using the Trails B. MRI data were acquired using a single 1.5 Tesla General Electric Signa System. Whole brain volumetric measurements were made on spoiled-gradient images employing MEASURE, a software package that uses stereological principles. Results: In the patient sample, no significant associations were found between performance on any neuropsychological measure and whole brain volume. In the control sample, a positive correlation emerged between full-scale IQ and whole brain volume (r=0.48, P=0.02). Conclusion: Normal structure/function relationships change in pathological states. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/94058 |
Appears in Collections: | Scholarly Works - FacM&SPsy |
Files in This Item:
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Relationship_of_whole_brain_volume_MRI_measures_to_neuropsychological_performance_in_schizophrenic_and_healthy_subjects_2000.pdf | 191.67 kB | Adobe PDF | View/Open |
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